When the theft of a top-secret spy agency's bioweapon forces a global manhunt, an anthropomorphic crocodile, once an elite but disgraced agent, finds himself reluctantly partnered with Cartman, a cunning yet insufferable South Park teenager roped into espionage by sheer accident. Together, they must infiltrate shadowy criminal syndicates, outpace rival operatives, and decipher the true purpose of a sinister conspiracy, even as their uneasy camaraderie deepens into an unlikely bond capable of challenging their own fractured morals.